Red Sox at Orioles prediction: Odds, expert picks, starting pitchers, betting trends, and stats for August 25

Its Monday, August 25 and the Red Sox (71-60) are in Baltimore to begin a series against the Orioles (60-70).

Following a series win over the Yankees in the Bronx over the weekend, the Sox will send Brennan Bernardino to the bump against Tomoyuki Sugano for Baltimore.

Lets dive into the matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch the first pitch, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch Red Sox at Orioles

• Date: Monday, August 25, 2025
• Time: 6:35PM EST
• Site: Oriole Park at Camden Yards
• City: Baltimore, MD
• Network/Streaming: NESN, MASN

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Red Sox at the Orioles

The latest odds as of Monday:

• Moneyline: Red Sox (-119), Orioles (-100)
• Spread: Red Sox -1.5
• Total: 9.0 runs

Probable starting pitchers for Red Sox at Orioles

• Pitching matchup for August 25, 2025: Brennan Bernardino vs. Tomoyuki Sugano
  • Red Sox: Brennan Bernardino (4-2, 2.93 ERA)
    Last outing: August 24 at Yankees – 0.00 ERA, 0 Earned Runs Allowed, 5 Hits Allowed, 0 Walks, and 3 Strikeouts
  • Orioles: Tomoyuki Sugano (10-5, 3.98 ERA)
    Last outing: August 19 at Boston – 0.00 ERA, 0 Earned Runs Allowed, 5 Hits Allowed, 0 Walks, and 3 Strikeouts

Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!

Top betting trends & insights to know ahead of Red Sox at Orioles

• The Over is 4-1 in the Orioles’ last 5 games against American League teams
• The Red Sox have covered in 4 of their last 5 road games but they are profiting 2.24 units
• The Red Sox have won 4 of their last 5 road games against teams with losing records
• Trevor Story was 4-14 (.286) in the series against the Yankees
• Trevor Story is hitting .309 (25-81) this month
• Alex Bregman was 7-16 (.438) against the Yankees over the weekend

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends toolon NBC Sports!

Expert picks & predictions for tonight’s game between the Red Sox and the Orioles

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Monday’s game between the Red Sox and the Orioles:

• Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
• Spread: NBC Sports Bet is leaning towards a play ATS on the Baltimore Orioles at +1.5.
• Total: NBC Sports Bet is staying away from a play on the Game Total of 9.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page fromNBC

Follow our experts on socials to keep up with all the latest content from the staff:

• Jay Croucher (@croucherJD)
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• Vaughn Dalzell (@VmoneySports)
• Brad Thomas (@MrBradThomas)